EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress

Oxidative stress: link between hypertension and diabetes

Gene regulation by small RNAs

The 5 annual international RNAi conference at Oxford, RNAi2010: Gene Regulation by Small RNAs, was held at St Hilda’s College, Oxford, UK (17-18 March). The meeting brought together experts from industry and academia and served as a forum to discuss new technological developments and interesting findings in the RNAi field. Research posters were displayed throughout the conference. Key sponsors ...

RNAi2010: Gene Regulation by Small RNAs

The Argonaute proteins constitute a highly conserved family of nucleic acid-binding proteins whose members have been implicated in RNA interference (RNAi) and related phenomena in several organisms. In particular, Argonaute 2 (Ago2) represents one of the key players in the RNA induced silencing complex (RISC). However, recently published literature describes that Ago2 itself is regulated under ...

Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress

Oxidative stress (OS) refers to the imbalance between the generation of reactive oxygen species (ROS) and the ability to scavenge these ROS by endogenous antioxidant systems, where ROS overwhelms the antioxidant capacity. Excessive presence of ROS results in irreversible damage to cell membranes, DNA, and other cellular structures by oxidizing lipids, proteins, and nucleic acids. Oxidative stre...

Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease

Objective. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between diabetes mellitus and periodontal changes. Materials and Methods. Tissue samples from ten adult patients with type 2 diabetes mellitus (T2D) and eight...